Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate

Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (EB/EV/OHPC), sold under the brand name Sin-Ol, is a combination medication of estradiol benzoate (EB), an estrogen, estradiol valerate (EV), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin, which was reportedly used as a combined injectable contraceptive in women in the early 1970s.^[1] It contained 1 mg EB, 10 mg EV, and 250 mg OHPC in oil solution, was provided in the form of 3 mL ampoules, and was administered by intramuscular injection at regular intervals.^[1] The medication was manufactured by the pharmaceutical company Reuffer in Mexico.^[1]

Estradiol benzoate /
estradiol valerate /
hydroxyprogesterone caproate

Combination of
Estradiol benzoate	Estrogen
Estradiol valerate	Estrogen
Hydroxyprogesterone caproate	Progestogen
Clinical data
Trade names	Sin-Ol
Other names	EB/EV/OHPC
Routes of administration	Intramuscular injection

See also

• Estradiol benzoate/estradiol phenylpropionate
• Estradiol/estradiol enanthate
• List of combined sex-hormonal preparations § Estrogens and progestogens