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Estradiol benzoate butyrate/algestone acetophenide
Combination drug From Wikipedia, the free encyclopedia
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Estradiol benzoate butyrate/algestone acetophenide, also known as estradiol benzoate butyrate/dihydroxyprogesterone acetophenide (EBB/DHPA) and sold under the brand names Neolutin N, Redimen, Soluna, and Unijab, is a form of combined injectable birth control which is used in Peru and Singapore.[1][2][3][4][5][6] It contains estradiol benzoate butyrate (EBB), an estrogen, and algestone acetophenide (dihydroxyprogesterone acetophenide; DHPA), a progestin.[2][3] The medication is given once per month by injection into muscle.[3]
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Medical uses
EBB/DHPA is used as a once-a-month combined injectable contraceptive to prevent pregnancy in women.[1][2][3]
Available forms
EBB/DHPA contains 10 mg estradiol benzoate butyrate (EBB), an estrogen, and 150 mg algestone acetophenide (dihydroxyprogesterone acetophenide; DHPA), a progestin.[2][3]
Pharmacology
Pharmacodynamics
EBB/DHPA has been said to have relatively weak estrogenic activity and has been described as "progestogen-dominant".[1]
Pharmacokinetics
EBB is said to have a shorter duration than estradiol enantate of about 3 weeks.[7] EBB/DHPA was developed because it was thought that the duration of EBB would be more suitable for use as a once-monthly combined injectable contraceptive than estradiol enantate in estradiol enantate/algestone acetophenide.[7]
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Society and culture
Brand names
EBB/DHPA is marketed under the brand names Neolutin N, Redimen, Soluna, and Unijab.[1][2][3][4][5][6][8] It was originally developed under the tentative brand name Unimens, but ultimately was not marketed under this particular brand name.[1][7][9][10][11]
Availability
See also
References
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