Estradiol valerate/dienogest

Estradiol valerate/dienogest (EV/DNG), sold under the brand names Lafamme, Natazia and Qlaira among others, is a combination product of estradiol valerate, an estrogen, and dienogest, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women. It is taken by mouth.

Estradiol valerate / dienogest

Estradiol valerate (top) and dienogest (bottom)
Combination of
Estradiol valerate	Estrogen
Dienogest	Progestogen
Clinical data
Trade names	Lafamme, Natazia, Qlaira
Other names	EV/DNG; SH T00658ID; Bay 86-5027; BAY86-5027
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601050
License data	US DailyMed: Estradiol_and_dienogest
Pregnancy category	AU: B3[1] Contraindicated[1]
Routes of administration	By mouth
Drug class	Estrogen; Progestogen
ATC code	G03AB08 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
CAS Number	307334-58-3
PubChem CID	9874560
KEGG	D10461

Birth control pills containing EV/DNG are associated with a significantly increased risk of venous thromboembolism.^[2] However, they are associated with a significantly lower risk of venous thromboembolism than birth control pills containing ethinylestradiol and a progestin.^[2]

See also

• Estradiol valerate/cyproterone acetate
• Estradiol/nomegestrol acetate
• List of combined sex-hormonal preparations