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Estropipate
Estrogen medication From Wikipedia, the free encyclopedia
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Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.[1][2][3][4] It is a salt of estrone sulfate and piperazine, and is transformed into estrone and estradiol in the body.[2][3] It is taken by mouth.[1]
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Medical uses
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Estropipate is used to:[1][additional citation(s) needed]
- Alleviate symptoms of menopause as menopausal hormone therapy
- Treat some types of infertility
- Treat some conditions leading to underdevelopment of female sexual characteristics
- Treat vaginal atrophy
- Treat some types of breast cancer (particularly in men and postmenopausal women)
- Treat prostate cancer
- Prevent osteoporosis
Available forms
Estropipate was available in the form of 0.75, 1.5, 3, and 6 mg oral tablets and 1.5 mg/gram vaginal cream. Estropipate is no longer available in the United States.
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Pharmacology
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Pharmacodynamics
Estropipate is a prodrug of estrone and estradiol. Hence, it is an estrogen, or an agonist of the estrogen receptors.
Pharmacokinetics
Estropipate is hydrolyzed into estrone in the body.[5] Estrone can then be transformed into estradiol by 17β-hydroxysteroid dehydrogenase.
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Chemistry
History
Estropipate was introduced for medical use by Abbott in 1968.[6] It was approved by the FDA in the United States in 1991.[7]
Society and culture
Generic names
Estropipate is the generic name of the drug and its INN , USAN , and BAN .[2][3][8][5][9]
Brand names
Estropipate was marketed under the brand names Genoral, Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others.[9][2][8][5]
Availability
Estropipate has been discontinued in the United States. In the past, estropipate has also been marketed in Canada, the United Kingdom, Ireland, Switzerland, Australia, South Africa, Mexico, and Indonesia.[9][8][5]
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References
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