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Ethylmagnesium bromide
Chemical compound From Wikipedia, the free encyclopedia
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Ethylmagnesium bromide is a Grignard reagent with formula CH3CH2MgBr, often abbreviated to EtMgBr, where Et is ethyl group. It is widely used in the laboratory synthesis of organic compounds.
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Reactions
Apart from acting as the synthetic equivalent of an ethyl anion synthon for nucleophilic addition, ethylmagnesium bromide may be used as a strong base to deprotonate various substrates such as alkynes:[1]
- RC≡CH + EtMgBr → RC≡CMgBr + EtH
In this application, ethylmagnesium bromide has been supplanted by the wide availability of organolithium reagents.
Preparation
Ethylmagnesium bromide is commercially available, usually as a solution in diethyl ether or tetrahydrofuran. It may be prepared in the normal manner of Grignard reagents — by reacting bromoethane with magnesium in diethyl ether:[2]
- EtBr + Mg → EtMgBr
References
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