Examples of in vivo transdifferentiation by lineage-instructive approach

A list of examples of in vivo transdifferentiation through transfection:^[1]

• mouse hepatocytes → B cells (Pdx1)^[2]
• exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)^[3]
• nonsensory cells → inner hair cells (Atoh1 and MathI)^[4]
• non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)^[5]

Through excision:

• B-cell precursors → hematopoietic progenitors(-Pax5)^[6]
• In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)^[7]

See also

• Transdifferentiation
• Induced stem cells