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Excision BioTherapeutics
American biotechnology company From Wikipedia, the free encyclopedia
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Excision BioTherapeutics is a biopharmaceutical company based in San Francisco focused on developing gene therapies against HIV infection.
The company has a single, CRISPR–Cas9 based therapy, EBT-101, under investigation. Initial investigation into the therapy was conducted by the lab of Kamel Khalili, a professor at Temple University.[1][2][3][4] In July 2023 the US Food and Drug Administration granted EBT-101 fast-track status.[5] In October 2023 an early-stage study on 3 people reported that the treatment appeared to be safe with no major side effects.[6] In March 2024 it was revealed that EBT-101 did not maintain HIV viral suppression when used alone at the initial dose tested, although it might have delayed viral rebound in one trial participant. One possible explanation for the viral rebound is that EBT-101 did not reach all of the cells that harboured latent HIV.
As of 2024 it has not been disclosed what the future holds for EBT-101, and whether or not dosing will continue in the Phase 1/2 trial. A long-term follow-up study of HIV-1 infected adults who received EBT-101 was also started. [7]
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