Amlodipine/valsartan

Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine, as the besilate, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin II receptor antagonist.^[6] This combination is usually well tolerated and effective for the reduction of blood pressure.^[7]

Amlodipine/valsartan

Combination of
Amlodipine	Calcium channel blocker
Valsartan	Angiotensin II receptor antagonist
Clinical data
Trade names	Exforge, Copalia, Dafiro
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Amlodipine and valsartan
Pregnancy category	AU: D[1]
Routes of administration	By mouth
ATC code	C09DB01 (WHO)
Legal status
Legal status	US: ℞-only[2] EU: Rx-only[3][4][5]
Identifiers
CAS Number	1190398-97-0
PubChem CID	11354874
ChemSpider	13092186 Y
KEGG	D09745 Y with HCTZ: D10286 Y
CompTox Dashboard (EPA)	DTXSID10180185
(verify)

The combination was approved for medical use in the European Union in January 2007,^[3] and in the United States in June 2007.^[8]

The combination is also available with hydrochlorothiazide.^[9][10] It was approved for medical use in the United States in April 2009,^[11] and in the European Union in November 2009.^[12][13][14]