Exodeoxyribonuclease (lambda-induced)

Exodeoxyribonuclease (lambda-induced) (EC 3.1.11.3, lambda exonuclease, phage lambda-induced exonuclease, Escherichia coli exonuclease IV, E. coli exonuclease IV, exodeoxyribonuclease IV, exonuclease IV) is an exonuclease.^[1][2] This enzyme catalyses the following chemical reaction

Exonucleolytic cleavage in the 5′- to 3′-direction to yield nucleoside 5′-phosphates

Exodeoxyribonuclease (lambda-induced)
Identifiers
EC no.	3.1.11.3
CAS no.	37367-70-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme has preference for double-stranded DNA (dsDNA). This means that it degrades a single strand of dsDNA, primarily any strand which has a phosphate at its 5' end.^[3]