XRN1 (gene)

5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ direction.^[5][6]

XRN1
Identifiers
Aliases	XRN1, SEP1, 5'-3' exoribonuclease 1, Xrn1
External IDs	OMIM: 607994; MGI: 891964; HomoloGene: 5894; GeneCards: XRN1; OMA:XRN1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 142,306,607 bp[1] End 142,448,062 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 95,836,813 bp[2] End 95,939,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell Achilles tendon germinal epithelium visceral pleura parietal pleura tibia bone marrow cells gingival epithelium endothelial cell palpebral conjunctiva Top expressed in tail of embryo cumulus cell Rostral migratory stream thymus genital tubercle zygote pineal gland secondary oocyte vas deferens granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding nucleic acid binding nuclease activity exonuclease activity hydrolase activity RNA binding G-quadruplex RNA binding G-quadruplex DNA binding 5'-3' exoribonuclease activity telomerase RNA binding 5'-3' exonuclease activity Cellular component membrane plasma membrane nucleus cytoplasm cytosol dendrite soma synapse P-body Biological process regulation of mRNA stability rRNA catabolic process nuclear mRNA surveillance histone mRNA catabolic process negative regulation of translation response to testosterone cellular response to cycloheximide RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to puromycin negative regulation of telomere maintenance via telomerase nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54464 24127 Ensembl ENSG00000114127 ENSMUSG00000032410 UniProt Q8IZH2 P97789 RefSeq (mRNA) NM_001042604 NM_001282857 NM_001282859 NM_019001 NM_011916 NM_001311130 RefSeq (protein) NP_001269786 NP_001269788 NP_061874 n/a Location (UCSC) Chr 3: 142.31 – 142.45 Mb Chr 9: 95.84 – 95.94 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the 5′-3′ exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including transcription, translation, homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.

See also

• Xrn2