FCN2

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene.^[2][3]

FCN2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2J0G, 2J0H, 2J0Y, 2J1G, 2J2P, 2J3F, 2J3G, 2J3O, 2J3U, 2J61, 4NYT, 4R9J, 4R9T
Identifiers
Aliases	FCN2, EBP-37, FCNL, P35, ficolin-2, ficolin 2
External IDs	OMIM: 601624; HomoloGene: 3031; GeneCards: FCN2; OMA:FCN2 - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver spleen pituitary gland subcutaneous adipose tissue prostate right lobe of thyroid gland kidney anterior pituitary minor salivary glands left lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding protein binding mannan binding metal ion binding calcium-dependent protein binding carbohydrate binding proteoglycan binding serine-type endopeptidase activity Cellular component extracellular region collagen blood microparticle extracellular exosome Biological process immune system process complement activation, lectin pathway complement activation recognition of apoptotic cell opsonization defense response to Gram-positive bacterium innate immune response proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2220 n/a Ensembl n/a n/a UniProt Q15485 n/a RefSeq (mRNA) NM_004108 NM_015837 NM_015838 NM_015839 n/a RefSeq (protein) NP_004099 NP_056652 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]