FFAR2-FFAR3 receptor heteromer

The FFAR2–FFAR3 receptor heteromer is a receptor heteromer consisting of free fatty acid receptors, FFAR2 and FFAR3 protomers.

free fatty acid receptor 2
Identifiers
Symbol	FFAR2
Alt. symbols	GPR43, FFA2R
NCBI gene	2867
HGNC	4501
OMIM	603823
RefSeq	NM_005306
UniProt	O15552
Other data
Locus	Chr. 19 q13.1
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free fatty acid receptor 3
Identifiers
Symbol	FFAR3
Alt. symbols	GPR41, FFA3R
NCBI gene	2865
HGNC	4499
OMIM	603821
RefSeq	NM_005304
UniProt	O14843
Other data
Locus	Chr. 19 q13.1
Search for Structures Swiss-model Domains InterPro

Signal transduction

The signalling of the FFAR2-FFAR3 receptor heteromer is distinct from that of the parent receptor homomers. The FFAR2-FFAR3 heteromer displays enhanced intracellular calcium release and Arrestin beta 2 recruitment. The heteromer also lacks the ability to inhibit the cAMP-dependent pathway but gained the ability to induce P38 mitogen-activated protein kinases.^[1]