FF domain

FF domains are short protein domains of about 50 amino acids. The domain was discovered by multiple sequence alignments. FF domains have been found in various transcription factors, splicing proteins, and signaling proteins. FF domains and WW domains often occur together in proteins.^[1]

Domain found in FBP11, CA150, and PRP40
Crystal structure of the TCERG1 FF4-6 tandem repeat domain
Identifiers
Symbol	FF
Pfam	PF01846
InterPro	IPR002713
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The structure of the FF domain in CA150 (TCERG1) was solved in 2009^[2] with refinements in 2013.^[3]

FF domains are protein interaction domains and thus can mediate the interaction among different proteins, such as various splicing proteins in the spliceosome. For instance, the interaction of yeast splicing proteins Prp40 and Luc7 is mediated by FF domains.^[4]