FGIN-143

FGIN-1-43 is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It is thought to produce anxiolytic effects by stimulating steroidogenesis of neuroactive steroids such as allopregnanolone, and is several times more potent than the related drug FGIN-127.^[1][2][3][4]

FGIN-143

Identifiers
IUPAC name 2-[2-(4-chlorophenyl)-5-chloro-1H-indol-3-yl]-N,N-dihexylacetamide
CAS Number	145040-29-5
PubChem CID	3995234
ChemSpider	3214029
UNII	C68RF62SNJ
CompTox Dashboard (EPA)	DTXSID50398444
Chemical and physical data
Formula	C28H36Cl2N2O
Molar mass	487.51 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cc(Cl)ccc3-c2[nH]c1ccc(Cl)cc1c2CC(=O)N(CCCCCC)CCCCCC
InChI InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3 Key:XTZUPNNVXIMWAR-UHFFFAOYSA-N
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