Fucosyltransferase 3

Galactoside 3(4)-L-fucosyltransferase is an enzyme that, in humans, is encoded by the FUT3 gene.^[3][4][5]

FUT3
Identifiers
Aliases	FUT3, CD174, FT3B, FucT-III, LE, Les, Fucosyltransferase 3, fucosyltransferase 3 (Lewis blood group)
External IDs	HomoloGene: 128031; GeneCards: FUT3; OMA:FUT3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 5,842,888 bp[1] End 5,851,474 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon nasal epithelium mucosa of ileum oral cavity rectum minor salivary glands mucosa of pharynx buccal mucosa cell duodenum amniotic fluid n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity alpha-(1->3)-fucosyltransferase activity fucosyltransferase activity glycosyltransferase activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome membrane Golgi membrane Biological process cell-cell recognition oligosaccharide biosynthetic process protein glycosylation macromolecule glycosylation fucosylation ceramide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2525 n/a Ensembl ENSG00000171124 n/a UniProt P21217 n/a RefSeq (mRNA) NM_000149 NM_001097639 NM_001097640 NM_001097641 NM_001374740 n/a RefSeq (protein) NP_000140 NP_001091108 NP_001091109 NP_001091110 NP_001361669 NP_001369673 NP_001369674 NP_001369675 NP_001369676 NP_001369677 NP_001369678 NP_001369679 n/a Location (UCSC) Chr 19: 5.84 – 5.85 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play essential roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed onto red blood cells, giving rise to the Lewis phenotype.

This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for most Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified for this gene.^[5]

See also

• Cluster of differentiation