Frizzled-1

Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.^[5][6]

FZD1
Identifiers
Aliases	FZD1, frizzled class receptor 1
External IDs	OMIM: 603408; MGI: 1196625; HomoloGene: 20750; GeneCards: FZD1; OMA:FZD1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 91,264,433 bp[1] End 91,271,326 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 2.61 cM Start 4,803,839 bp[2] End 4,808,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lactiferous duct visceral pleura tail of epididymis tendon of biceps brachii Epithelium of choroid plexus parietal pleura trigeminal ganglion superficial temporal artery hair follicle spinal ganglia Top expressed in gastrula calvaria vas deferens umbilical cord habenula hair follicle aortic valve decidua ascending aorta endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding frizzled binding signal transducer activity Wnt-protein binding protein binding Wnt-activated receptor activity signaling receptor binding transmembrane signaling receptor activity G protein-coupled receptor activity Cellular component Wnt signalosome membrane focal adhesion plasma membrane cell surface integral component of membrane Biological process G protein-coupled receptor signaling pathway positive regulation of protein phosphorylation autocrine signaling epithelial cell differentiation muscular septum morphogenesis ventricular septum morphogenesis cell-cell signaling membranous septum morphogenesis outflow tract morphogenesis positive regulation of DNA-binding transcription factor activity Wnt signaling pathway planar cell polarity pathway involved in neural tube closure negative regulation of BMP signaling pathway positive regulation of transcription, DNA-templated multicellular organism development cell surface receptor signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation hard palate development neuron differentiation canonical Wnt signaling pathway negative regulation of transcription, DNA-templated signal transduction Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation beta-catenin destruction complex disassembly Wnt signaling pathway, planar cell polarity pathway presynapse assembly negative regulation of oxidative stress-induced neuron death non-canonical Wnt signaling pathway positive regulation of neuron projection development negative regulation of canonical Wnt signaling pathway regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8321 14362 Ensembl ENSG00000157240 ENSMUSG00000044674 UniProt Q9UP38 O70421 RefSeq (mRNA) NM_003505 NM_021457 RefSeq (protein) NP_003496 NP_067432 Location (UCSC) Chr 7: 91.26 – 91.27 Mb Chr 5: 4.8 – 4.81 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.^[6]