Frizzled-2

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.^[5][6][7]

FZD2
Identifiers
Aliases	FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
External IDs	OMIM: 600667; MGI: 1888513; HomoloGene: 20377; GeneCards: FZD2; OMA:FZD2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,557,484 bp[1] End 44,561,262 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 102,495,222 bp[2] End 102,498,884 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo spinal ganglia ganglionic eminence stromal cell of endometrium trigeminal ganglion glomerulus metanephric glomerulus retinal pigment epithelium right coronary artery Top expressed in external carotid artery internal carotid artery ureter medullary collecting duct mandibular prominence vas deferens fossa maxillary prominence condyle ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component cytoplasm clathrin-coated endocytic vesicle membrane membrane focal adhesion plasma membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway epithelial cell differentiation muscular septum morphogenesis ventricular septum morphogenesis cell-cell signaling membranous septum morphogenesis outflow tract morphogenesis positive regulation of DNA-binding transcription factor activity Wnt signaling pathway planar cell polarity pathway involved in neural tube closure positive regulation of transcription, DNA-templated multicellular organism development sensory perception of smell cell surface receptor signaling pathway inner ear receptor cell development hard palate development cochlea morphogenesis neuron differentiation canonical Wnt signaling pathway signal transduction beta-catenin destruction complex disassembly Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway positive regulation of G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2535 57265 Ensembl ENSG00000180340 ENSMUSG00000050288 UniProt Q14332 Q9JIP6 RefSeq (mRNA) NM_001466 NM_020510 RefSeq (protein) NP_001457 NP_065256 Location (UCSC) Chr 17: 44.56 – 44.56 Mb Chr 11: 102.5 – 102.5 Mb PubMed search [3] [4]
Wikidata
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.^[7]