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Frizzled-3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Frizzled-3
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Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.[5][6][7]

Quick Facts FZD3, Identifiers ...
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Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]

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See also

References

Further reading

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