Frizzled-4

Frizzled-4 (Fz-4) is a protein that in humans is encoded by the FZD4 gene.^[5][6][7] Fz-4 has also been designated as CD344 (cluster of differentiation 344).

FZD4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BPB, 5BPQ, 5BQC, 5BQE, 5CL1, 5CM4
Identifiers
Aliases	FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4, frizzled class receptor 4
External IDs	OMIM: 604579; MGI: 108520; HomoloGene: 7325; GeneCards: FZD4; OMA:FZD4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.2 Start 86,945,679 bp[1] End 86,955,395 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D3|7 49.32 cM Start 89,053,563 bp[2] End 89,062,342 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in adipose tissue subcutaneous adipose tissue right lung abdominal fat parietal pleura synovial joint tendon of biceps brachii pericardium seminal vesicula thoracic diaphragm Top expressed in retinal pigment epithelium choroid plexus of fourth ventricle ciliary body internal carotid artery Epithelium of choroid plexus epithelium of stomach ankle subcutaneous adipose tissue white adipose tissue external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein homodimerization activity signal transducer activity protein binding protein heterodimerization activity Wnt-activated receptor activity ubiquitin protein ligase binding transmembrane signaling receptor activity cytokine binding G protein-coupled receptor activity Wnt-protein binding amyloid-beta binding signaling receptor activity protein-containing complex binding Cellular component clathrin-coated endocytic vesicle membrane membrane cell-cell junction plasma membrane integral component of plasma membrane cell surface extracellular exosome integral component of membrane clathrin-coated vesicle membrane dendrite synapse glutamatergic synapse Biological process negative regulation of cell-substrate adhesion cellular response to retinoic acid G protein-coupled receptor signaling pathway luteinization extracellular matrix-cell signaling positive regulation of JUN kinase activity positive regulation of DNA-binding transcription factor activity hearing Wnt signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway vasculogenesis positive regulation of transcription, DNA-templated multicellular organism development cerebellum vasculature morphogenesis cell surface receptor signaling pathway progesterone secretion blood vessel development neuron differentiation retinal blood vessel morphogenesis canonical Wnt signaling pathway substrate adhesion-dependent cell spreading locomotion involved in locomotory behavior retina vasculature morphogenesis in camera-type eye signal transduction Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway membrane organization non-canonical Wnt signaling pathway positive regulation of neuron projection arborization cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8322 14366 Ensembl ENSG00000174804 ENSMUSG00000049791 UniProt Q9ULV1 Q61088 RefSeq (mRNA) NM_012193 NM_008055 RefSeq (protein) NP_036325 NP_032081 Location (UCSC) Chr 11: 86.95 – 86.96 Mb Chr 7: 89.05 – 89.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins.^[8] FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.^[7]

See also

• Frizzled