Frizzled-6

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.^[5][6][7]

FZD6
Identifiers
Aliases	FZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDs	OMIM: 603409; MGI: 108474; HomoloGene: 2617; GeneCards: FZD6; OMA:FZD6 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 103,298,433 bp[1] End 103,332,866 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 15.22 cM Start 38,869,429 bp[2] End 38,901,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell caput epididymis Epithelium of choroid plexus skin of thigh skin of hip corpus epididymis epithelium of nasopharynx palpebral conjunctiva secondary oocyte hair follicle Top expressed in lip uterus genital tubercle lens esophagus zone of skin heart spermatocyte urethra lower respiratory tract More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding Wnt-activated receptor activity ubiquitin protein ligase binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding amyloid-beta binding Cellular component membrane apical part of cell integral component of plasma membrane cell surface apicolateral plasma membrane apical plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle plasma membrane integral component of membrane Biological process hair follicle development G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway establishment of planar polarity cell proliferation in midbrain Wnt signaling pathway negative regulation of DNA-binding transcription factor activity platelet activation multicellular organism development Wnt signaling pathway, planar cell polarity pathway embryonic nail plate morphogenesis cell surface receptor signaling pathway neural tube closure inner ear morphogenesis midbrain morphogenesis negative regulation of canonical Wnt signaling pathway signal transduction midbrain development Wnt signaling pathway, calcium modulating pathway establishment of body hair planar orientation canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8323 14368 Ensembl ENSG00000164930 ENSMUSG00000022297 UniProt O60353 Q61089 RefSeq (mRNA) NM_001164615 NM_001164616 NM_003506 NM_001317796 NM_001162494 NM_008056 RefSeq (protein) NP_001158087 NP_001158088 NP_001304725 NP_003497 NP_001158087.1 NP_003497.2 NP_001155966 NP_032082 Location (UCSC) Chr 8: 103.3 – 103.33 Mb Chr 15: 38.87 – 38.9 Mb PubMed search [3] [4]
Wikidata
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.^[7] Fz-6 is believed to be the receptor for the WNT4 ligand.^[8]

Interactions

Fz-6 has been shown to interact with secreted frizzled-related protein 1.^[9]