Frizzled-7

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.^[5][6][7]

FZD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	OMIM: 603410; MGI: 108570; HomoloGene: 20751; GeneCards: FZD7; OMA:FZD7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 202,033,855 bp[1] End 202,038,441 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2|1 30.08 cM Start 59,521,583 bp[2] End 59,526,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle germinal epithelium urethra lactiferous duct tibia parotid gland cerebellar vermis parietal pleura cardiac muscle tissue of right atrium seminal vesicula Top expressed in vestibular membrane of cochlear duct medullary collecting duct renal corpuscle ascending aorta vestibular sensory epithelium Epithelium of choroid plexus aortic valve saccule triceps brachii muscle masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding frizzled binding signal transducer activity Wnt-protein binding protein binding transmembrane signaling receptor activity phosphatidylinositol-4,5-bisphosphate binding G protein-coupled receptor activity Wnt-activated receptor activity Cellular component integral component of membrane membrane plasma membrane recycling endosome membrane endosome endosome membrane Biological process negative regulation of cell-substrate adhesion cellular response to retinoic acid G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway regulation of transcription, DNA-templated positive regulation of epithelial cell proliferation involved in wound healing T cell differentiation in thymus non-canonical Wnt signaling pathway via JNK cascade negative regulation of ectodermal cell fate specification somatic stem cell division positive regulation of JNK cascade Wnt signaling pathway stem cell population maintenance positive regulation of transcription, DNA-templated multicellular organism development cell surface receptor signaling pathway skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration neuron differentiation canonical Wnt signaling pathway substrate adhesion-dependent cell spreading positive regulation of phosphorylation signal transduction mesenchymal to epithelial transition Wnt signaling pathway, planar cell polarity pathway negative regulation of cardiac muscle cell differentiation regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8324 14369 Ensembl ENSG00000155760 ENSMUSG00000041075 UniProt O75084 Q61090 RefSeq (mRNA) NM_003507 NM_008057 RefSeq (protein) NP_003498 NP_032083 Location (UCSC) Chr 2: 202.03 – 202.04 Mb Chr 1: 59.52 – 59.53 Mb PubMed search [3] [4]
Wikidata
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.^[7]

Interactions

Fz-7 has been shown to interact with DLG4.^[8]