Frizzled-8

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.^[5][6]

FZD8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IJY, 4F0A
Identifiers
Aliases	FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs	OMIM: 606146; MGI: 108460; HomoloGene: 40606; GeneCards: FZD8; OMA:FZD8 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.21 Start 35,638,247 bp[1] End 35,642,296 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A1|18 4.91 cM Start 9,212,163 bp[2] End 9,218,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cartilage tissue ganglionic eminence retinal pigment epithelium tendon of biceps brachii trabecular bone lactiferous duct pancreatic epithelial cell pancreatic ductal cell spinal ganglia Top expressed in ventricular zone hypoblast calvaria retinal pigment epithelium left lobe of liver ankle ciliary body molar primitive endoderm trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity signaling receptor binding ubiquitin protein ligase binding protein binding signal transducer activity PDZ domain binding G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity Cellular component integral component of membrane membrane plasma membrane Golgi apparatus Wnt-Frizzled-LRP5/6 complex Biological process positive regulation of protein phosphorylation positive regulation of JUN kinase activity cell surface receptor signaling pathway G protein-coupled receptor signaling pathway angiogenesis positive regulation of transcription by RNA polymerase II multicellular organism development negative regulation of transcription by RNA polymerase II neuron differentiation signal transduction Wnt signaling pathway T cell differentiation in thymus non-canonical Wnt signaling pathway canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8325 14370 Ensembl ENSG00000177283 ENSMUSG00000036904 UniProt Q9H461 Q61091 RefSeq (mRNA) NM_031866 NM_008058 RefSeq (protein) NP_114072 NP_032084 Location (UCSC) Chr 10: 35.64 – 35.64 Mb Chr 18: 9.21 – 9.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.^[6]