Frizzled-9

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.^[5][6][7] Fz-9 has also been designated as CD349 (cluster of differentiation 349).

FZD9
Identifiers
Aliases	FZD9, CD349, FZD3, frizzled class receptor 9
External IDs	OMIM: 601766; MGI: 1313278; HomoloGene: 2619; GeneCards: FZD9; OMA:FZD9 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 73,433,778 bp[1] End 73,436,120 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 75.08 cM Start 135,277,792 bp[2] End 135,280,084 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue muscle of thigh gastrocnemius muscle Amygdala cingulate gyrus anterior cingulate cortex prefrontal cortex C1 segment Hypothalamus right frontal lobe Top expressed in rib myotome soleus muscle lumbar subsegment of spinal cord lumbar spine ventricular zone stria vascularis plantaris muscle larynx extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity signal transducer activity Wnt-protein binding protein heterodimerization activity transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-activated receptor activity Cellular component cytoplasm membrane plasma membrane cell surface perinuclear region of cytoplasm filopodium membrane endoplasmic reticulum membrane Golgi apparatus mitochondrial membranes integral component of membrane postsynapse glutamatergic synapse Biological process G protein-coupled receptor signaling pathway Wnt signaling pathway nervous system development multicellular organism development cell surface receptor signaling pathway learning or memory neuroblast proliferation B cell differentiation signal transduction ossification release of cytochrome c from mitochondria positive regulation of bone mineralization positive regulation of apoptotic process negative regulation of neuron apoptotic process regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization negative regulation of necroptotic process positive regulation of canonical Wnt signaling pathway negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of skeletal muscle acetylcholine-gated channel clustering bone regeneration positive regulation of neural precursor cell proliferation non-canonical Wnt signaling pathway canonical Wnt signaling pathway postsynapse organization regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8326 14371 Ensembl ENSG00000188763 ENSMUSG00000049551 UniProt O00144 Q9R216 RefSeq (mRNA) NM_003508 NM_010246 RefSeq (protein) NP_003499 NP_034376 Location (UCSC) Chr 7: 73.43 – 73.44 Mb Chr 5: 135.28 – 135.28 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.^[7]