Tyrosine-protein kinase Fes/Fps

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.^[5][6] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.^[7]

FES
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93
Identifiers
Aliases	FES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
External IDs	OMIM: 190030; MGI: 95514; HomoloGene: 37563; GeneCards: FES; OMA:FES - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,883,695 bp[1] End 90,895,776 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D2|7 45.65 cM Start 80,027,504 bp[2] End 80,037,694 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte right lung upper lobe of left lung blood sural nerve apex of heart right lobe of liver left uterine tube Top expressed in granulocyte bone marrow stroma of bone marrow tibiofemoral joint ankle joint blood spleen mesenteric lymph nodes internal carotid artery body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity microtubule binding immunoglobulin receptor binding non-membrane spanning protein tyrosine kinase activity kinase activity protein binding phosphatidylinositol binding ATP binding lipid binding protein tyrosine kinase activity Cellular component cytoplasm cytosol Golgi apparatus membrane focal adhesion microtubule cytoskeleton extrinsic component of cytoplasmic side of plasma membrane plasma membrane cell junction cytoskeleton cytoplasmic vesicle Biological process phosphorylation regulation of vesicle-mediated transport regulation of cell motility multicellular organism development chemotaxis protein phosphorylation regulation of cell adhesion regulation of cell population proliferation microtubule bundle formation regulation of cell shape positive regulation of neuron projection development positive regulation of microtubule polymerization peptidyl-tyrosine autophosphorylation regulation of cell differentiation protein autophosphorylation peptidyl-tyrosine phosphorylation regulation of mast cell degranulation cell population proliferation innate immune response positive regulation of actin cytoskeleton reorganization positive regulation of myeloid cell differentiation epidermal growth factor receptor signaling pathway cell migration centrosome cycle cell adhesion positive regulation of monocyte differentiation cellular response to vitamin D Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2242 14159 Ensembl ENSG00000182511 ENSMUSG00000053158 UniProt P07332 P16879 RefSeq (mRNA) NM_001143783 NM_001143784 NM_001143785 NM_002005 NM_010194 RefSeq (protein) NP_001137255 NP_001137256 NP_001137257 NP_001996 NP_034324 Location (UCSC) Chr 15: 90.88 – 90.9 Mb Chr 7: 80.03 – 80.04 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.^[8]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1^[9] and BCR gene.^[10][11]