Fenpiverinium

Fenpiverinium is an anticholinergic and antispasmodic compound;^[1] it is marketed as a combination drug with pitofenone hydrochloride and either nimesulide or metamizole in Eastern Europe and India to treat smooth muscle spasms and pain.^[2]

Fenpiverinium

Clinical data
ATC code	A03AB21 (WHO)
Identifiers
IUPAC name 1-(4-Amino-4-oxo-3,3-diphenylbutyl)-1-methylpiperidinium
CAS Number	258329-46-3 Y
PubChem CID	71490
ChemSpider	64566
UNII	KP2L8LC73B
CompTox Dashboard (EPA)	DTXSID7048376
Chemical and physical data
Formula	C22H29N2O+
Molar mass	337.487 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[N+]1(CCCCC1)CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
InChI InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1 Key:QDIYJDPBMZUZEH-UHFFFAOYSA-O
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The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000^[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.^[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;^[5][6] the order was overturned in December and appealed by the Government in January 2017.^[7]