FHOD1

FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene.^[5][6][7]

FHOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DAD
Identifiers
Aliases	FHOD1, FHOS, formin homology 2 domain containing 1
External IDs	OMIM: 606881; MGI: 2679008; HomoloGene: 40860; GeneCards: FHOD1; OMA:FHOD1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,229,387 bp[1] End 67,247,481 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,055,795 bp[2] End 106,074,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen gastrocnemius muscle upper lobe of left lung muscle of thigh right lung apex of heart granulocyte right lobe of thyroid gland glutes right adrenal cortex Top expressed in granulocyte inner renal medulla glomerulus left lung lobe muscle of thigh neural layer of retina upper arm knee joint body of femur skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding identical protein binding protein domain specific binding protein self-association Cellular component cell projection bleb membrane nucleus cytoskeleton stress fiber cytoplasm cytosol intercalated disc Biological process positive regulation of stress fiber assembly nuclear migration establishment of centrosome localization positive regulation of transcription by RNA polymerase II regulation of stress fiber assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29109 234686 Ensembl ENSG00000135723 ENSMUSG00000014778 UniProt Q9Y613 Q6P9Q4 RefSeq (mRNA) NM_013241 NM_001318202 NM_177699 RefSeq (protein) NP_001305131 NP_037373 NP_808367 Location (UCSC) Chr 16: 67.23 – 67.25 Mb Chr 8: 106.06 – 106.07 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.^[7]

Interactions

FHOD1 has been shown to interact with RAC1.^[8]