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Fladrafinil

Wakefulness-promoting drug From Wikipedia, the free encyclopedia

Fladrafinil
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Fladrafinil (developmental code name CRL-40,941), also known as fluorafinil or as bisfluoroadrafinil, is a wakefulness-promoting agent related to modafinil that was never marketed.[1][2][3] It is sold online and used non-medically as a nootropic (cognitive enhancer).[1][2][3]

Quick Facts Clinical data, Other names ...

Modafinil and its analogues are known to act as dopamine reuptake inhibitors and this is thought to be involved in their wakefulness-promoting effects.[1] Chemically, fladrafinil is a derivative of adrafinil (N-hydroxymodafinil) and is also known as bisfluoroadrafinil (it is the bis(4-fluoro) phenyl ring-substituted derivative of adrafinil).[1] It is closely related to flmodafinil (CRL-40,940; bisfluoromodafinil).[1][2][3]

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Pharmacology

Fladrafinil has been found to produce antiaggressive effects in animals, which adrafinil does not produce.[4][failed verification] Fladrafinil is purportedly 3 to 4 times more potent than adrafinil in this action.[4]

Chemistry

Analogues of fladrafinil include modafinil, armodafinil ((R)-modafinil), esmodafinil ((S)-modafinil), adrafinil (CRL-40,028; N-hydroxymodafinil), flmodafinil (CRL-40,940; bisfluoromodafinil), and CE-123, among others.[2]

History

Fladrafinil appears to have first been patented in the 1980s.[5]

Research

The pharmacokinetics of fladrafinil are being studied.[6]

References

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