FlmA-FlmB toxin-antitoxin system
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The FlmA-FlmB toxin-antitoxin system consists of FlmB RNA (F leading-region maintenance B), a family of non-coding RNAs and the protein toxin FlmA. The FlmB RNA transcript is 100 nucleotides in length and is homologous to sok RNA from the hok/sok system and fulfills the identical function as a post-segregational killing (PSK) mechanism.[1][2]
| flmB | |
|---|---|
Conserved secondary structure of flmB RNA. | |
| Identifiers | |
| Symbol | FlmB |
| Other data | |
| RNA type | antisense RNA |
| Domain(s) | E. coli, S. enterica |
| PDB structures | PDBe |
flmB is found on the F-plasmid of Escherichia coli and Salmonella enterica. It is responsible for stabilising the plasmid. If the plasmid is not inherited, long-lived FlmA mRNA and protein will be highly toxic to the cell, possibly to the point of causing cell death.[2] Daughter cells which inherit the plasmid inherit the FlmB gene, coding for FlmB RNA which binds the leader sequence of FlmA mRNA and represses its translation.[1]
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