VEGFR1

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.^[5]

FLT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
Identifiers
Aliases	FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1, vascular endothelial growth factor receptor 1, fms related receptor tyrosine kinase 1
External IDs	OMIM: 165070; MGI: 95558; HomoloGene: 134179; GeneCards: FLT1; OMA:FLT1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.3 Start 28,300,346 bp[1] End 28,495,145 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G3|5 87.01 cM Start 147,498,414 bp[2] End 147,662,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium placenta endothelial cell right ventricle myocardium of left ventricle dorsal motor nucleus of vagus nerve cardia thyroid gland left lobe of thyroid gland internal globus pallidus Top expressed in right lung right lung lobe internal carotid artery myocardium of ventricle muscle of thigh external carotid artery umbilical cord cardiac muscle tissue of left ventricle islet of Langerhans substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity transferase activity nucleotide binding protein kinase activity placental growth factor-activated receptor activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding growth factor binding vascular endothelial growth factor binding Cellular component cytoplasm integral component of membrane endosome focal adhesion membrane receptor complex integral component of plasma membrane extracellular region extracellular space plasma membrane actin cytoskeleton Biological process positive regulation of vascular endothelial growth factor receptor signaling pathway cell differentiation blood vessel morphogenesis vascular endothelial growth factor receptor-1 signaling pathway positive regulation of MAP kinase activity monocyte chemotaxis positive regulation of phospholipase C activity transmembrane receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor signaling pathway phosphorylation positive regulation of angiogenesis positive regulation of phosphatidylinositol 3-kinase activity multicellular organism development chemotaxis protein phosphorylation vascular endothelial growth factor receptor signaling pathway embryonic morphogenesis angiogenesis protein autophosphorylation positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cellular response to vascular endothelial growth factor stimulus cell migration positive regulation of MAPK cascade positive regulation of cell population proliferation positive regulation of cell migration sprouting angiogenesis positive regulation of ERK1 and ERK2 cascade negative regulation of vascular endothelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2321 14254 Ensembl ENSG00000102755 ENSMUSG00000029648 UniProt P17948 P35969 RefSeq (mRNA) NM_001159920 NM_001160030 NM_001160031 NM_002019 NM_010228 NM_001363135 RefSeq (protein) NP_001153392 NP_001153502 NP_001153503 NP_002010 NP_034358 NP_001350064 Location (UCSC) Chr 13: 28.3 – 28.5 Mb Chr 5: 147.5 – 147.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, and placental growth factor. The sequence structure of the FLT1 gene resembles that of the FMS (now CSF1R) gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.^[6]

The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of white adipose tissue to brown adipose tissue as well as increase brown adipose angiogenesis in mice.^[7]

Functional genetic variation in FLT1 (rs9582036) has been found to affect non-small cell lung cancer survival.^[8]

Interactions

FLT1 has been shown to interact with PLCG1^[9] and vascular endothelial growth factor B (VEGF-B).^[10][11]

See also

• VEGF receptors