Fluorometholone acetate

Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester.^{[1][2][3][4]: 186} It is the C17α acetate ester of fluorometholone.^[1][2][3]

Fluorometholone acetate

Clinical data
Trade names	Flarex, Florate, Omnitrol
Other names	Oxylone acetate; 1-Dehydro-9α-fluoro-11β,17α-dihydroxy-6α-methylprogesterone 17α-acetate; 17α-Acetoxy-9α-fluoro-11β-hydroxy-6α-methylpregna-1,4-diene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid; Progestogen
Identifiers
IUPAC name [(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS Number	3801-06-7
PubChem CID	240767
ChemSpider	210390
UNII	9I50C3I3OK
KEGG	D04221
ChEBI	CHEBI:78354
ChEMBL	ChEMBL1201064
CompTox Dashboard (EPA)	DTXSID20191424
ECHA InfoCard	100.021.156
Chemical and physical data
Formula	C24H31FO5
Molar mass	418.505 g·mol−1
3D model (JSmol)	Interactive image
SMILES [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@]([H])(O)[C@@]1(F)[C@@]2([H])C[C@]([H])(C)C2=CC(=O)C=C[C@]12C
InChI InChI=1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17-,19-,20-,21-,22-,23-,24-/m0/s1

In addition to its potent corticosteroid activity, fluorometholone acetate is a progestogen.^[4] It has been studied in the treatment of breast cancer in women and has been found to be effective, producing remission in about 20% of women with advanced breast cancer at an oral dosage of 50 mg/day.^[4] However, it also produces severe Cushing's syndrome-like symptoms like plethora, moon face, glycosuria, marked weight gain, hypertension, and osteoporosis at this dosage due to its glucocorticoid activity.^[4]

See also

• Flumedroxone acetate
• Mometasone furoate