Flurithromycin

Flurithromycin is a second generation macrolide antibiotic. It is a fluorinated derivative of erythromycin A.^[1] It is a broad spectrum antibiotic with similar bactericidal action to erythromycin. Unlike erythromycin, flurithromycin is more tolerant of acidic environments, meaning more survives the digestion process, resulting in higher serum levels, and more efficacious elimination of susceptible bacteria, including staphylococcus aureus and streptococcus pyogenes.^[2]

Flurithromycin

Clinical data
ATC code	J01FA14 (WHO)
Identifiers
IUPAC name (3R,4S,5S,6R,7R,9S,11R,12R,13S,14R)-6- [(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy- 6-methyloxan-2-yl]oxy-14-ethyl-9-fluoro-7,12, 13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy- 4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9, 11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
CAS Number	82664-20-8 Y
PubChem CID	71260
ChemSpider	64388 Y
UNII	56C9DTE69V
KEGG	D07242 Y
ChEBI	CHEBI:131719 N
ChEMBL	ChEMBL2106403 N
CompTox Dashboard (EPA)	DTXSID40905085
ECHA InfoCard	100.126.548
Chemical and physical data
Formula	C37H66FNO13
Molar mass	751.927 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C3O[C@H](CC)[C@](O)(C)[C@H](O)[C@H](C(=O)[C@](F)(C)C[C@](O)(C)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@H]([C@H](O[C@@H]2O[C@H]([C@H](O)[C@](OC)(C2)C)C)[C@H]3C)C)C
InChI InChI=1S/C37H66FNO13/c1-14-24-37(10,46)29(42)21(5)28(41)34(7,38)17-35(8,45)31(52-33-26(40)23(39(11)12)15-18(2)48-33)19(3)27(20(4)32(44)50-24)51-25-16-36(9,47-13)30(43)22(6)49-25/h18-27,29-31,33,40,42-43,45-46H,14-17H2,1-13H3/t18-,19+,20-,21+,22+,23+,24-,25+,26-,27+,29-,30+,31-,33+,34+,35-,36-,37-/m1/s1 Y Key:XOEUHCONYHZURQ-HNUBZJOYSA-N Y
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