Flutrimazole

Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and higher than bifonazole.^[1]

Flutrimazole

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	D01AC16 (WHO) G01AF18 (WHO)
Identifiers
IUPAC name (RS)-1-[(2-Fluorophenyl)(4-fluorophenyl)benzyl]-1H-imidazole
CAS Number	119006-77-8 Y
PubChem CID	3401
ChemSpider	3284 Y
UNII	776S0UP252
KEGG	D07193 Y
ChEBI	CHEBI:82864 N
ChEMBL	ChEMBL2107430 N
CompTox Dashboard (EPA)	DTXSID30869622
ECHA InfoCard	100.170.770
Chemical and physical data
Formula	C22H16F2N2
Molar mass	346.381 g·mol−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES Fc1ccc(cc1)C(c2c(F)cccc2)(c3ccccc3)n4ccnc4
InChI InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H Y Key:QHMWCHQXCUNUAK-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Mechanism of action

It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol 14 α-demethylase.^{[citation needed]}

See also

• Clotrimazole