Gamma-glutamyl hydrolase

Gamma-glutamyl hydrolase is an enzyme^[5][6][7][8] that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

Gamma-glutamyl hydrolase
Identifiers
EC no.	3.4.19.9
CAS no.	9074-87-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

GGH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L9X
Identifiers
Aliases	GGH, GH, gamma-glutamyl hydrolase, GATD10
External IDs	OMIM: 601509; MGI: 1329035; HomoloGene: 2881; GeneCards: GGH; OMA:GGH - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.3 Start 63,014,881 bp[1] End 63,039,407 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 20,042,052 bp[2] End 20,066,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum kidney tubule ventricular zone mucosa of sigmoid colon mucosa of transverse colon right lobe of liver human penis ganglionic eminence gonad glomerulus Top expressed in parotid gland lacrimal gland left colon submandibular gland esophagus Epithelium of choroid plexus pyloric antrum skin of external ear pancreas skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function exopeptidase activity omega peptidase activity hydrolase activity gamma-glutamyl-peptidase activity Cellular component melanosome cytosol lysosome extracellular exosome nucleus extracellular region extracellular space azurophil granule lumen specific granule lumen tertiary granule lumen vacuole Biological process response to insulin response to zinc ion response to ethanol proteolysis neutrophil degranulation tetrahydrofolylpolyglutamate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8836 14590 Ensembl ENSG00000137563 ENSMUSG00000073987 UniProt Q92820 Q9Z0L8 RefSeq (mRNA) NM_003878 NM_010281 RefSeq (protein) NP_003869 NP_034411 Location (UCSC) Chr 8: 63.01 – 63.04 Mb Chr 4: 20.04 – 20.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.^[7][9][10] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.^[10]

Nomenclature

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".