Folate receptor

Folate receptors bind folate and reduced folic acid derivatives and mediates delivery of tetrahydrofolate to the interior of cells.^[1] It is then converted from monoglutamate to polyglutamate forms - such as 5-methyltetrahydrofolate - as only monoglutamate forms can be transported across cell membranes. Polyglutamate forms are biologically active enzymatic cofactors required for many folate-dependent processes such as folate-dependent one-carbon metabolism. These proteins are attached to the membrane by a GPI anchor.^[2] A riboflavin-binding protein required for the transport of riboflavin to the developing oocyte in chicken also belong to this family.

Folate receptor family
Identifiers
Symbol	Folate_rec
Pfam	PF03024
InterPro	IPR004269
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Human proteins from this family include:

• FOLR1: folate receptor 1 (adult),
• FOLR2: folate receptor 2 (fetal), and
• FOLR3: folate receptor gamma.