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Fringe gene

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Fringe genes are important in the workings of the notch signaling pathway.[1]

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In Drosophila melanogaster (the fruit fly) the fringe gene (fng) was identified as part of the notch mechanism by Dr. Kenneth Irvine at the Waksman Institute at Rutgers.[citation needed] Later based on similarity, the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG)[2][3] genes were identified in mammals.

Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases (GlcNAcT) glycosyltransferases.

The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.

The mouse and human Fringe family members map to three different chromosomes:

  • Mfng maps to mouse Chr 15 and to human Chr 22.
  • Lfng maps to mouse Chr 5 and human Chr 7.
  • Rfng maps to mouse Chr 11 and human Chr 17.
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