MFNG

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,^[5][6][7] a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).^[8][9]

MFNG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J0A, 2J0B
Identifiers
Aliases	MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 602577; MGI: 1095404; HomoloGene: 1803; GeneCards: MFNG; OMA:MFNG - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,469,063 bp[1] End 37,486,393 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.69 cM Start 78,640,082 bp[2] End 78,657,675 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood lymph node spleen appendix apex of heart bone marrow cell right lung upper lobe of left lung Top expressed in ventricular zone medial ganglionic eminence subcutaneous adipose tissue Rostral migratory stream white adipose tissue mesenteric lymph nodes lactiferous gland thymus spleen tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity metal ion binding glycosyltransferase activity acetylglucosaminyltransferase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi membrane Golgi apparatus membrane extracellular space Biological process pattern specification process multicellular organism development positive regulation of protein binding marginal zone B cell differentiation positive regulation of Notch signaling pathway regulation of Notch signaling pathway protein O-linked fucosylation blastocyst formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4242 17305 Ensembl ENSG00000100060 ENSMUSG00000018169 UniProt O00587 O09008 RefSeq (mRNA) NM_001166343 NM_002405 NM_008595 RefSeq (protein) NP_001159815 NP_002396 NP_032621 Location (UCSC) Chr 22: 37.47 – 37.49 Mb Chr 15: 78.64 – 78.66 Mb PubMed search [3] [4]
Wikidata
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They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.^[7]