Fructuronate reductase

In enzymology, fructuronate reductase (EC 1.1.1.57) is an enzyme that catalyzes the chemical reaction

D-mannonic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

keto-D-fructuronic acid

+ NADH

 

fructuronate reductase
Identifiers
EC no.	1.1.1.57
CAS no.	9028-44-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are D-mannonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are D-fructuronic acid (shown in its keto form), reduced NADH, and a proton.^[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannonate:NAD⁺ 5-oxidoreductase. Other names in common use include mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, and D-mannonate:NAD⁺ oxidoreductase. This enzyme participates in pentose and glucuronate interconversions.