GAIN domain

The GAIN domain (G-protein-coupled receptor (GPCR) autoproteolysis-inducing domain) is a protein domain found in a number of cell surface receptors, including adhesion-GPCRs and polycystic kidney disease proteins PKD1 and PKD2. The domain is involved in the self-cleavage of these transmembrane receptors, and has been shown to be crucial for their function ^{[citation needed]}.^[1] Point mutations within the GAIN domain of PKD1 and GPR56 are known to cause polycystic kidney disease and polymicrogyria, respectively.^[2][3][4]

GPCR-Autoproteolsis INducing (GAIN) domain, rat latrophilin 4DLQ​ mediates autocatalytic cleavage of adhesion GPCRs