Galanin receptor 3

Galanin receptor 3 (GAL₃) is a G-protein coupled receptor encoded by the GALR3 gene.^[5]

GALR3
Identifiers
Aliases	GALR3, Galanin receptor 3
External IDs	OMIM: 603692; MGI: 1329003; HomoloGene: 20798; GeneCards: GALR3; OMA:GALR3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,823,382 bp[1] End 37,825,485 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.7 cM Start 78,926,085 bp[2] End 78,927,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum nucleus accumbens skeletal muscle tissue right lobe of liver body of pancreas putamen Amygdala Hypothalamus muscle of thigh Top expressed in CA3 field intestinal villus Ileal epithelium embryo lactiferous gland yolk sac tracheobronchial tree inferior colliculi skin of abdomen islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function galanin receptor activity G protein-coupled receptor activity signal transducer activity peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane non-motile cilium cilium Biological process learning or memory phospholipase C-activating G protein-coupled receptor signaling pathway neuropeptide signaling pathway feeding behavior positive regulation of transcription by RNA polymerase II signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway chemical synaptic transmission G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger negative regulation of adenylate cyclase activity galanin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8484 14429 Ensembl ENSG00000128310 ENSMUSG00000114755 UniProt O60755 O88853 RefSeq (mRNA) NM_003614 NM_015738 RefSeq (protein) NP_003605 NP_056553 Location (UCSC) Chr 22: 37.82 – 37.83 Mb Chr 15: 78.93 – 78.93 Mb PubMed search [3] [4]
Wikidata
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Function

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts^[5]

See also

• Galanin receptor