GCAT

Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.^[3]

GCAT
Identifiers
Aliases	GCAT, KBL, glycine C-acetyltransferase
External IDs	OMIM: 607422; MGI: 1349389; HomoloGene: 8475; GeneCards: GCAT; OMA:GCAT - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver left ventricle oocyte endothelial cell prefrontal cortex Brodmann area 9 Amygdala nucleus accumbens cingulate gyrus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function glycine C-acetyltransferase activity transferase activity pyridoxal phosphate binding acyltransferase activity catalytic activity Cellular component mitochondrion nucleus nucleoplasm nuclear speck mitochondrial inner membrane Biological process cellular amino acid metabolic process metabolism biosynthesis threonine catabolic process L-threonine catabolic process to glycine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23464 26912 Ensembl n/a ENSMUSG00000006378 UniProt O75600 O88986 RefSeq (mRNA) NM_001171690 NM_014291 NM_001161712 NM_013847 RefSeq (protein) NP_001165161 NP_055106 NP_001155184 NP_038875 Location (UCSC) n/a n/a PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Function

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.