GFRA2 (gene)

GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene.^[5][6]

GFRA2
Identifiers
Aliases	GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2, GDNF family receptor alpha 2
External IDs	OMIM: 601956; MGI: 1195462; HomoloGene: 1145; GeneCards: GFRA2; OMA:GFRA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 21,690,398 bp[1] End 21,812,357 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 71,127,560 bp[2] End 71,217,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Brodmann area 10 left lobe of thyroid gland right lobe of thyroid gland right frontal lobe Brodmann area 9 primary visual cortex cingulate gyrus anterior cingulate cortex testicle Top expressed in left lung lobe median eminence lumbar spinal ganglion ascending aorta aortic valve lateral septal nucleus genital tubercle Gonadal ridge molar arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glial cell-derived neurotrophic factor receptor activity signaling receptor activity Cellular component anchored component of membrane membrane extrinsic component of membrane plasma membrane intracellular anatomical structure external side of plasma membrane receptor complex Biological process glial cell-derived neurotrophic factor receptor signaling pathway nervous system development transmembrane receptor protein tyrosine kinase signaling pathway MAPK cascade axon guidance positive regulation of peptidyl-serine phosphorylation of STAT protein negative regulation of protein autophosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2675 14586 Ensembl ENSG00000168546 ENSMUSG00000022103 UniProt O00451 O08842 RefSeq (mRNA) NM_001165038 NM_001165039 NM_001495 NM_008115 NM_001302094 NM_001302095 RefSeq (protein) NP_001158510 NP_001158511 NP_001486 NP_001289023 NP_001289024 NP_032141 Location (UCSC) Chr 8: 21.69 – 21.81 Mb Chr 14: 71.13 – 71.22 Mb PubMed search [3] [4]
Wikidata
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Function

The GFRA2 protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.^[6]

Interactions

GFRA2 (gene) has been shown to interact with GDNF.^[7][8]

See also

• GFRα