Gamma-glutamyltransferase 1

Gamma-glutamyltransferase 1 (GGT1), also known as CD224 (Cluster of Differentiation 224), is a human gene.^[5]

GGT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GDX, 4GG2, 4Z9O, 4ZBK, 4ZC6, 4ZCG
Identifiers
Aliases	GGT1, CD224, D22S672, D22S732, GGT, GGT 1, GTG, gamma-glutamyltransferase 1, GGTD
External IDs	OMIM: 612346; MGI: 95706; HomoloGene: 68450; GeneCards: GGT1; OMA:GGT1 - orthologs
EC number	3.4.19.13
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 24,594,811 bp[1] End 24,629,005 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 75,561,604 bp[2] End 75,586,200 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver mucosa of transverse colon gallbladder right lung body of pancreas upper lobe of left lung right lobe of thyroid gland human kidney left lobe of thyroid gland gonad Top expressed in right kidney proximal tubule human kidney intestinal villus duodenum seminal vesicula epithelium of small intestine jejunum decidua efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity peptidase activity protein binding acyltransferase activity hydrolase activity glutathione hydrolase activity hypoglycin A gamma-glutamyl transpeptidase activity peptidyltransferase activity leukotriene-C(4) hydrolase leukotriene C4 gamma-glutamyl transferase activity Cellular component integral component of membrane membrane plasma membrane extracellular exosome extracellular space Biological process leukotriene metabolic process zymogen activation glutathione biosynthetic process regulation of immune system process cysteine biosynthetic process spermatogenesis regulation of inflammatory response xenobiotic metabolic process glutamate metabolic process glutathione catabolic process proteolysis cellular amino acid metabolic process glutathione metabolic process fatty acid metabolic process leukotriene D4 biosynthetic process protein biosynthesis peptide modification response to estradiol response to lipopolysaccharide response to tumor necrosis factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2678 14598 Ensembl ENSG00000100031 ENSMUSG00000006345 UniProt P19440 Q60928 RefSeq (mRNA) NM_013430 NM_001032364 NM_001032365 NM_001288833 NM_005265 NM_013421 NM_008116 NM_001305992 RefSeq (protein) NP_001275762 NP_038265 NP_038347 NP_001292921 NP_032142 NP_001366466 NP_001366467 NP_001366468 NP_001366469 NP_001366470 Location (UCSC) Chr 22: 24.59 – 24.63 Mb Chr 10: 75.56 – 75.59 Mb PubMed search [3] [4]
Wikidata
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Function

Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.^[5]

See also

• Cluster of differentiation