Gamma-glutamyltransferase 5

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.^[5][6][7][8]

GGT5
Identifiers
Aliases	GGT5, GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDs	OMIM: 137168; MGI: 1346063; HomoloGene: 55802; GeneCards: GGT5; OMA:GGT5 - orthologs
EC number	3.4.19.14
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 24,219,654 bp[1] End 24,245,108 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 75,425,174 bp[2] End 75,453,034 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right coronary artery left lobe of thyroid gland left coronary artery left uterine tube canal of the cervix right auricle of heart gastric mucosa tibial nerve subcutaneous adipose tissue Top expressed in granulocyte stroma of bone marrow gastrula uterus cervix muscle of thigh mammary gland lactiferous gland decidua mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity peptidase activity acyltransferase activity hydrolase activity leukotriene-C(4) hydrolase glutathione hydrolase activity hypoglycin A gamma-glutamyl transpeptidase activity peptidyltransferase activity leukotriene C4 gamma-glutamyl transferase activity Cellular component plasma membrane membrane integral component of membrane intrinsic component of plasma membrane Biological process leukotriene metabolic process glutathione biosynthetic process inflammatory response proteolysis cellular amino acid metabolic process glutathione metabolic process glutathione catabolic process leukotriene biosynthetic process leukotriene D4 biosynthetic process fatty acid metabolic process protein biosynthesis glutamate metabolic process cysteine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2687 23887 Ensembl ENSG00000099998 ENSMUSG00000006344 UniProt P36269 Q9Z2A9 RefSeq (mRNA) NM_001099781 NM_001099782 NM_001302464 NM_001302465 NM_004121 NM_011820 NM_001359425 RefSeq (protein) NP_001093251 NP_001093252 NP_001289393 NP_001289394 NP_004112 NP_035950 NP_001346354 Location (UCSC) Chr 22: 24.22 – 24.25 Mb Chr 10: 75.43 – 75.45 Mb PubMed search [3] [4]
Wikidata
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Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.^[8]