Gamma-glutamyltransferase 7

Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.^[5][6][7]

GGT7
Identifiers
Aliases	GGT7, D20S101, GGT4, GGTL3, GGTL5, dJ18C9.2, gamma-glutamyltransferase 7
External IDs	OMIM: 612342; MGI: 1913385; HomoloGene: 70866; GeneCards: GGT7; OMA:GGT7 - orthologs
EC number	3.4.19.13
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 34,844,720 bp[1] End 34,872,856 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,490,379 bp[2] End 155,518,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary apex of heart right frontal lobe right lobe of thyroid gland Brodmann area 9 left lobe of thyroid gland gastrocnemius muscle olfactory zone of nasal mucosa gastric mucosa Top expressed in nasal epithelium olfactory epithelium superior frontal gyrus primary visual cortex cerebellar cortex lateral geniculate nucleus medial dorsal nucleus medial geniculate nucleus pontine nuclei dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glutathione hydrolase activity acyltransferase activity protein binding hydrolase activity hypoglycin A gamma-glutamyl transpeptidase activity leukotriene C4 gamma-glutamyl transferase activity peptidyltransferase activity Cellular component integral component of membrane membrane plasma membrane Biological process glutathione biosynthetic process proteolysis glutathione catabolic process glutathione metabolic process leukotriene D4 biosynthetic process negative regulation of response to oxidative stress protein biosynthesis cellular amino acid metabolic process glutamate metabolic process cysteine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2686 207182 Ensembl ENSG00000131067 ENSMUSG00000027603 UniProt Q9UJ14 Q99JP7 RefSeq (mRNA) NM_178026 NM_001351702 NM_178025 NM_144786 NM_001362898 NM_001362900 RefSeq (protein) NP_821158 NP_001338631 NP_821158.2 NP_659035 NP_001349827 NP_001349829 Location (UCSC) Chr 20: 34.84 – 34.87 Mb Chr 2: 155.49 – 155.52 Mb PubMed search [3] [4]
Wikidata
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Function

Gamma-glutamyltransferase is a membrane-associated protein involved in both glutathione metabolism and the transpeptidation of amino acids. Changes in gamma-glutamyltransferase activity may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.^[7]