GHMP kinase family

In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes.^[1] These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP.^[2][3] The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.^[4]

GHMP kinases N terminal domain
crystal structure of the streptococcus pneumoniae phosphomevalonate kinase (pmk)
Identifiers
Symbol	GHMP_kinases_N
Pfam	PF00288
Pfam clan	CL0329
InterPro	IPR006204
PROSITE	PDOC00545
SCOP2	1fwl / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

GHMP kinases C terminal
pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium
Identifiers
Symbol	GHMP_kinases_C
Pfam	PF08544
InterPro	IPR013750
PROSITE	PDOC00545
SCOP2	1fwl / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary