Glucagon-like peptide-2 receptor

Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.^[5]

GLP2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 7D68
Identifiers
Aliases	GLP2R, entrez:9340, glucagon like peptide 2 receptor
External IDs	OMIM: 603659; MGI: 2136733; HomoloGene: 3132; GeneCards: GLP2R; OMA:GLP2R - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 9,822,206 bp[1] End 9,892,099 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 67,552,328 bp[2] End 67,661,979 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle epithelium of colon gallbladder muscle layer of sigmoid colon transverse colon gastric mucosa rectum mucosa of transverse colon gonad canal of the cervix Top expressed in neural layer of retina Hindgut midgut jejunum ileum colon urinary bladder dentate gyrus of hippocampal formation granule cell duodenum rectum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity glucagon receptor activity transmembrane signaling receptor activity signal transducer activity G protein-coupled peptide receptor activity peptide hormone binding Cellular component integral component of membrane plasma membrane membrane Biological process cellular response to glucagon stimulus cell surface receptor signaling pathway positive regulation of cell population proliferation signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9340 93896 Ensembl ENSG00000065325 ENSMUSG00000049928 UniProt O95838 Q5IXF8 RefSeq (mRNA) NM_004246 NM_175681 RefSeq (protein) NP_004237 NP_783612 Location (UCSC) Chr 17: 9.82 – 9.89 Mb Chr 11: 67.55 – 67.66 Mb PubMed search [3] [4]
Wikidata
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Function

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).^[6]

See also

• Glucagon-like peptide-2