GLYCAM1

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.^[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.^{[citation needed]} Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.^[3]

glycosylation dependent cell adhesion molecule-1
Identifiers
Symbol	GLYCAM1
NCBI gene	644076
HGNC	18023
RefSeq	XM_927461
UniProt	Q8IVK1
Other data
Locus	Chr. 12 q13.2
Search for Structures Swiss-model Domains InterPro

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.^[1]

External links

• GlyCAM-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)