Platelet glycoprotein VI

Platelet glycoprotein VI (GPVI) is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GP6 gene.^[5] It was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.

GP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GI7
Identifiers
Aliases	GP6, BDPLT11, GPIV, GPVI, glycoprotein VI platelet
External IDs	OMIM: 605546; MGI: 1889810; HomoloGene: 9488; GeneCards: GP6; OMA:GP6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,013,705 bp[1] End 55,038,264 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,366,964 bp[2] End 4,400,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle gonad blood granulocyte cerebellar hemisphere right hemisphere of cerebellum bone marrow cells primary visual cortex skin of abdomen Top expressed in blood bone marrow spleen zygote yolk sac genital tubercle liver heart skeleton leg More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity collagen binding signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane tetraspanin-enriched microdomain extracellular exosome membrane integral component of plasma membrane Biological process platelet activation hemostasis blood coagulation enzyme linked receptor protein signaling pathway leukocyte migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51206 243816 Ensembl ENSG00000088053 ENSG00000274050 ENSG00000278670 ENSG00000276211 ENSG00000277439 ENSG00000278316 ENSG00000275633 ENSG00000274566 ENSG00000275931 ENSG00000276065 ENSMUSG00000078810 UniProt Q9HCN6 P0C191 RefSeq (mRNA) NM_016363 NM_001083899 NM_001256017 NM_001163014 RefSeq (protein) NP_001077368 NP_001242946 NP_057447 NP_001156486 Location (UCSC) Chr 19: 55.01 – 55.04 Mb Chr 7: 4.37 – 4.4 Mb PubMed search [3] [4]
Wikidata
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Function

GPVI is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.^[6][7]

Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.

Interactions

GPVI has been shown to interact with LYN.^[8]

See also

• collagen receptor