Glypican 5

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.^[5][6]

GPC5
Identifiers
Aliases	GPC5, glypican 5
External IDs	OMIM: 602446; MGI: 1194894; HomoloGene: 3285; GeneCards: GPC5; OMA:GPC5 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.3 Start 91,398,621 bp[1] End 92,873,682 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 115,329,647 bp[2] End 116,762,591 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle caudate nucleus putamen endothelial cell nucleus accumbens entorhinal cortex pons superior vestibular nucleus amygdala external globus pallidus Top expressed in substantia nigra globus pallidus deep cerebellar nuclei dorsal tegmental nucleus otolith organ utricle paraventricular nucleus of hypothalamus lateral hypothalamus inferior colliculi medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding Cellular component integral component of plasma membrane extracellular region membrane anchored component of membrane Golgi lumen plasma membrane lysosomal lumen extracellular space anchored component of plasma membrane integral component of membrane collagen-containing extracellular matrix cell surface Biological process glycosaminoglycan biosynthetic process retinoid metabolic process glycosaminoglycan catabolic process regulation of signal transduction cell migration positive regulation of canonical Wnt signaling pathway regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2262 103978 Ensembl ENSG00000179399 ENSMUSG00000022112 UniProt P78333 Q8CAL5 RefSeq (mRNA) NM_004466 NM_175500 RefSeq (protein) NP_004457 NP_780709 Location (UCSC) Chr 13: 91.4 – 92.87 Mb Chr 14: 115.33 – 116.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.^[6]

See also

• Glypican