Glypican 6

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.^[5][6]

GPC6
Identifiers
Aliases	GPC6, OMIMD1, Glypican 6
External IDs	OMIM: 604404; MGI: 1346322; HomoloGene: 55922; GeneCards: GPC6; OMA:GPC6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.3-q32.1 Start 93,226,807 bp[1] End 94,408,020 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 117,162,727 bp[2] End 118,213,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue tibia vena cava superficial temporal artery saphenous vein seminal vesicula pancreatic epithelial cell spinal ganglia synovial membrane caput epididymis Top expressed in ascending aorta aortic valve external carotid artery internal carotid artery sciatic nerve genital tubercle maxillary prominence mandibular prominence tail of embryo human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway protein binding Cellular component Golgi lumen nucleus integral component of plasma membrane extracellular region anchored component of membrane lysosomal lumen membrane plasma membrane extracellular space anchored component of plasma membrane collagen-containing extracellular matrix glutamatergic synapse cell surface synapse Biological process glycosaminoglycan metabolic process retinoid metabolic process cell migration glycosaminoglycan biosynthetic process glycosaminoglycan catabolic process Wnt signaling pathway, planar cell polarity pathway regulation of signal transduction regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10082 23888 Ensembl ENSG00000183098 ENSMUSG00000058571 UniProt Q9Y625 Q9R087 RefSeq (mRNA) NM_005708 NM_001079844 NM_011821 RefSeq (protein) NP_005699 NP_001073313 NP_035951 Location (UCSC) Chr 13: 93.23 – 94.41 Mb Chr 14: 117.16 – 118.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.^[6]

See also

• Glypican